Our i-Fect transfection kit was one of the first products. This has resulted in it being widely used and frequently published.
We kick off 2018 with some new publications. Here we feature a study where researchers use our kit to deliver G-protein-coupled receptor C (MrgprC) siRNA in vivo. This receptor is part of the TRPV1 pathway.
- Ying-jun Liu, Xiao-xi Lin, Jian-qiao Fang, and Fang Fang. Involvement of MrgprC in electroacupuncture analgesia for attenuating CFA-induced thermal hyperalgesia by suppressing the TRPV1 pathway. Pre-pub-full text PDF
Image: Expression of TRPV1 in rats treated with MrgrprC si RNA vs controls (C).
The others conclude that MrgprC expression is impacted by electroacupuncture and downregulates TRPV1. This is the mechanism that results in pain relief.