Monday, August 9, 2010

i-Fect, Survivin and Gliobastomas

I would like to add Survivin to the list of genes successfully silenced in-vitro and in-vivo using our i-FectTMsiRNA delivery kit.

The list includes: DOR, hTERT, The β3 subunit of the Na+,K+-ATPase, rSNSR1, NTS1. NAV1.8 and more

Joseph George, Naren L. Banik and Swapan K. Ray. Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo. Neuro-Oncology, doi:10.1093/neuonc/noq079.

...survivin siRNA cDNA was suspended in RNAse free sterile water (25 μg DNA/10 μl) and mixed (1:4 v/v) with i-Fect transfection reagent (Neuromics)...

Delivery of the Surivivin siRNA resulted in significant decreases in Glioblatoma Tumor Size.

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